Posted by Chemlink in Chemlink Lab, Pharmaceutical Products | 0 comments
The Chemlink Specialities pharma team are hosting two seminar days on Feb 11th and 12th 2020. The seminar days are free to attend and interested parties should book a place quickly to avoid disappointment.
The main focus of this seminar will be how we can improve the solubility of poorly water soluble drugs using Hot Melt Extrusion. The day will include technical demonstrations and speakers from industry and academia.
When: 11th or 12th Feb 2020. Delegates are invited to attend one full day only, please specify your preference in your reply. Please note: 11th is fully booked – we are now only taking bookings for the 12th Feb.
Where: The seminar will take place at the Core Additive Technologies offices in Chester, Cheshire. Click to see the exact location. Join us for dinner and entertainment the evening before your seminar day at The Alchemist in Chester. Our recommended local accommodation is the DoubleTree Hilton in Chester where Chemlink Specialities’ guests can book bed and breakfast for £115. Spa access is an additional £15.
What: The seminar will focus on improving the solubility of poorly water soluble drugs using Hot Melt Extrusion and will feature equipment from Thermofisher.
- Rotational Rheometer
- Hot Melt Extrusion
- Down Streaming – Pelletiser
- Introduction to Solubility Enhancement – Shilpa Mistry
- Pre-Screening Study for HME – Dr. Daniel Treffer, Melt Prep
- Personalized medicines, 3D printing – Dr. Shen Qi, University of East Anglia
- “Extrusion and downstream process of Hypromellose Acetate Succinate (HPMCAS)”.- Mr. Shogo Warashina, Shin-Etsu
- “Science-based HME Process Development, Transfer and Scale-up” – Josip Matic (RCPE)
Who: This seminar is aimed at beginners and experts in the field who would like to understand the newest technology and see the most recent excipients to enhance the solubility of the drugs and process ability on the market. Several professionals will be attending to present and demonstrate hot melt techniques, we will release a detailed timetable to confirmed attendees shortly.
What Is Hot Melt Extrusion?
Solid dispersion (SD) has been widely used to improve the dissolution rate, solubility, and oral absorption of poor water-soluble drugs. SD refers to the group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug; the matrix can be either crystalline or amorphous. Solid dispersion was first introduced to overcome the low bioavailability of lipophilic drugs by forming eutectic mixture of drugs with water soluble carriers. Approximate 40% of new chemical entities (NCE) being synthesised by combinatorial screening programs possessing superior pharmacological activities are poorly soluble, which is a great obstacle in formulation development. Biopharmaceutical classification system (BCS) highlights the dissolution as rate limiting step for oral absorption of BCS class 2 and class 4 drugs. BCS class 2 and class 4 drugs have low solubility. A number of methodologies can be adapted to improve solubilisation of poor water-soluble drugs and further to improve its bioavailability.
Hot melt extrusion is a manufacturing technique that was originally established in the early 1930s for use in the plastics and food industries but is now gaining popularity in the pharmaceutical industry. Hot melt extrusion technology offers over traditional manufacturing techniques and provides an efficient production process that enhances the quality of products. In drug development, the main use of the method is the molecular dispersion of active pharmaceutical ingredients (APIs) into polymer matrices to form solid solutions.
Consequently, hot melt extrusion has been used for a range of applications, which includes enhancing the bioavailability of water-insoluble drugs by producing a solid solution, controlling drug release, masking the taste of bitter APIs, as well as creating thin films.
In this technical seminar, we guide you through pre-screening to down streaming using Hot Melt Extrusion. This seminar is aimed at beginners and experts in the field to understand this new technology and the recent excipients to enhance the solubility of the drugs and process ability.